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About

Codified Genomics was founded in 2013 in Houston, TX, primarily to serve genomic variant interpretation for researchers in the Texas Medical Center. Since then Codified has developed tools to serve clinical genomic interpretation around the country.

Matthew Bainbridge, Ph.D. CEO

Matthew has worked with high-throughput sequencing since its inception. At Canada's Michael Smith Genome Sciences Centre (BCGSC), he constructed the first algorithms for RNA seq, chip-seq, and structural rearrangement discovery for the 454 and Solexa sequencing platforms. He later received his PhD in structural and computational biology and molecular biophysics from his work at the Baylor College of Medicine Human Genome Sequencing Center (BCM-HGSC). There he helped develop the BCM-HGSC’s illumina analysis pipeline, capture-resequencing analytics and co-developed capture reagents, both regional and whole exome including some of the largest capture targets ever sequenced.

His analytic tools were central to the analysis of one the first personal genomes used for medical diagnostics[Lupski]. Later, he led the team that discovered the molecular cause of DRD in siblings. This information was used, for the first time, to alter the management and medications the children received. Later, he used WES to find a novel gene for  a previously undescribed disease, marking one of the first times WES was used to molecularly describe a disease prior to its clinical description. 

 

Eric Venner, Ph.D. CTO

Eric has a decade of experience using state-of-the-art computing technologies to address scientific problems in computational biology spanning genomics, variant analysis, clinical reporting and protein function prediction. He is responsible for the development and maintenance of bioinformatics pipelines that provide quality control metrics, alignment files, genomic annotation, and variant calls for whole genome and whole exome data. Additionally, he has expertise in variant interpretation, annotation and clinical reporting. He is a member of the Sequence Analysis working committee for NIH's Undiagnosed Diseases Network, a national, multi-site effort to systematically deal with difficult-to-diagnose, rare Mendelian diseases within a clinical setting and a member of the CSER Consortium sequence analysis and diagnostic yield working group. He has overseen development of a cloud-based data commons on Amazon Web Services and web-portals for the eMERGE project which facilitate collaboration and data exchange.

During his PhD at Baylor College of Medicine, he developed novel computational methods to predict and study protein function [PMID: 21179190, PMID: 23353650], and packaged those methods into useful software tools for researchers [PMID: 22689386, PMID: 19307237]. During my time as a software engineer, I worked on nearly a dozen projects and developed high quality commercial software tools for hundreds of users, striving deliver practical solutions on time and under budget.

 

Eric Boerwinkle, Ph.D. CSO

Eric Boerwinkle is dean and M. David Low Chair in Public Health at The University of Texas Health Science Center at Houston (UTHealth) School of Public Health. He began serving as dean on Jan. 1, 2016.  

Boerwinkle joined the UTHealth faculty in 1986 and served as chair of the Department of Epidemiology, Human Genetics and Environmental Health at UTHealth School of Public Health from 2003-2015. He has also directed the Human Genetics Center at the School of Public Health and the Brown Foundation Institute for Molecular Medicine (IMM) for the Prevention of Human Diseases, which are a part of UTHealth. He holds the Kozmetsky Family Chair in Human Genetics at the School of Public Health as well.

Author of more than 800 scientific papers, Boerwinkle has led groundbreaking research on the connection between genes and health. He and his colleagues completed the world’s first genome-wide analyses for a variety of cardiovascular disease risk factors, including hypertension and diabetes. These investigations have been a critical step in developing drugs that lower disease risk.

Boerwinkle earned a Ph.D. in human genetics from the University of Michigan, Ann Arbor, where he also earned master’s degrees in human genetics and statistics. In 2003, he was the recipient of the President’s Scholar Award, which recognizes distinguished achievements in research and education at UTHealth.

Boerwinkle has served on several national research panels, including the Advisory Council for the National Human Genome Research Institute and the Board of External Advisors for the National Heart, Lung and Blood Institute, part of the National Institutes of Health.

Boerwinkle has also served as an editor of several journals including CirculationEpidemiologyGenetic Epidemiology and the American Journal of Epidemiology.